Antibiotic discovery and development is the scientific process of finding, evaluating, and bringing into use new agents that kill or inhibit the growth of bacteria and other microorganisms. It spans the search for novel compounds, testing their activity against target pathogens, assessing safety and effectiveness, a…
Antibiotic discovery and development is the scientific process of finding, evaluating, and bringing into use new agents that kill or inhibit the growth of bacteria and other microorganisms. It spans the search for novel compounds, testing their activity against target pathogens, assessing safety and effectiveness, and advancing promising candidates toward clinical use. This work has become especially urgent because of antimicrobial resistance, in which bacteria evolve to withstand existing drugs, creating a continual need for new antibiotics and for evaluating how candidate agents perform against resistant strains. Research available through this journal addresses the activity of antibiotics against resistant organisms. A study reports the in vitro activity of iclaprim against methicillin-resistant Staphylococcus aureus that is nonsusceptible to daptomycin, linezolid, or vancomycin, examining how a candidate agent performs against bacteria resistant to established treatments. This page gathers peer-reviewed, open-access research relevant to antibiotic discovery and development, supporting readers seeking primary literature on new antimicrobial agents, their testing against drug-resistant pathogens, and the response to antimicrobial resistance.
1 peer-reviewed article, ranked by relevance. Each links to its DOI.