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Dec 2018 DOI 10.14302/issn.2578-8590.ipj-18-2556
J. Fernandes RicardoCorresponding author
Centre of Research, Education, Innovation and Intervention in Sport (CIFI2D), Faculty of Sport, University of Porto, Porto, Portugal
Swimming is a human activity that relies heavily on individual physiological capabilities. In fact, the swimming general performance equation, proposed several years ago by di Prampero 1, highlighted the energy expenditure, the propulsive efficiency and the hydrodynamic drag as its main determinants. Therefore, coaches and exercise physiologists have been proposing a number of testing protocols aiming to diagnose the swimmers physiological training status. However, most of these protocols are invasive, time consuming and costly (e.g. the oxygen uptake assessment and the blood lactate concentrations determination). In addition, some of these tests have some constraints, as the use of a cumbersome breathing valve for respiratory data collection (cf. 2) and the selection of an averaged value of blood lactate concentrations as an non individualized index of endurance performance 34.
Dec 2025
Liu LipingCorresponding author
The incidence rate of melasma is notably high among patients with anxiety disorders. Aromatherapy primarily influences the physiological and psychological states of individuals through the inhalation or application of essential oils, thereby facilitating the treatment or alleviation of various conditions. This study aims to explore the action mechanism of complex lemon-angelica sinensis -boswellia essential oil (CEO) in treating anxiety disorders with melasma. We investigated the active ingredients, targets, and pathways of CEO in relation to anxiety and melasma using network pharmacology. We employed cell assays and conducted nebulized essential oil inhalation tests on CUMS mice to validate the intervention effects of CEO on anxiety. A total of 28 active components, including neryl acetate, 3-butenylphthalide and octyl acetate, and 26 cross-targets, such as ESR1, CCND1 and PIK3CA, were identified. GO and KEGG pathway analyses indicated that these cross-targets were primarily involved in endocrine regulation, cell proliferation, and apoptosis, specifically through PI3K/Akt signaling pathway and calcium signaling pathway. The experimental results demonstrated that CEO significantly reduced the secretion of NO, TNF-a and IL-6, as well as the mRNA expressions of ESR1, CCND1 and PIK3CA in cells compared to the inflammatory cell model. Furthermore, CEO notably decreased the forced swimming immobility time of mice and the levels of IL-1β, ESR1 and CCND1 in hippocampus when compared to model mice. These findings suggest that CEO may regulate ESR1, CCND1 and PIK3CA through its citral, 3-butylphthalate and neryl acetate, thereby influencing endocrine function, cell proliferation and apoptosis, inhibiting inflammation and anxiety-like behavior in CUMS-induced mice.
Feb 2024 DOI 10.14302/issn.2474-7785.jarh-24-4967
Nikkhah AkbarCorresponding author
This editorial aims to propose and delineate that disciplined open-air exercise can slow down aging in humans. The aging process may be slowed down by outdoor physical training (e.g., mountaineering, climbing, running, swimming, walking, jogging) mainly because of fresh air inhalation and psychological calmness. However, for outdoor exercise to be a healthy asset, it should be performed in unpolluted and uncontaminated environments. Advanced public education policies must be developed to persuade people to maximize their outdoor physical activities. This is to ensure achieving peace and serenity for both body and psych. Integrated social activities may also be encouraged with open-air exercise. As such, stress in the third millennium can be pragmatically attenuated and managed. As a result of slower aging process, human life quality may improve worldwide.
May 2020 DOI 10.14302/issn.2641-4538.jphi-20-3338
Chibueze Izah SylvesterCorresponding author
Department of Microbiology, Faculty of Science, Bayelsa Medical University, Yenagoa, Bayelsa State, Nigeria
This study investigated the acute toxicity of Clariasgariepinusfingerlings. The fingerlings of Clariasgariepinuswere acclimatized for 1 week before the range-finding test was carried out at varying concentrations. Sublethal concentration (viz: 0.00ppm, 10.80 ppm, 18.00 ppm, 25.20 ppm, 32.40 ppm and 39.60 ppm of the 2,4-D Dimethylamine salt) were made in a rectangular aquarium. Each experimental concentration was carried out in triplicate with 10 fish each. The media were renewed at every 24 hours throughout the experimental duration viz: 96 hours. When the fish were introduced into the aquarium containing the toxicants, they exhibited some behavioural changes including opercular movement, air gulping and irregular swimming pattern. The mortality rate significantly increased as the concentration of the 2,4-D Dimethylamine salt increased for each of the exposure duration. The LC50 values at 24, 48, 72 and 96 were 86.15 ppm, 36.28 ppm, 18.72 ppm and 15.68 ppm, respectively. From the findings of this study, there is a need for exercise caution in the use of 2,4-D Dimethylamine salt based herbicides close to the aquatic ecosystem.
May 2019 DOI 10.14302/issn.2637-6075.jpae-19-2779
Chibueze Izah SylvesterCorresponding author
Department of Biological Sciences, Bayelsa Medical University, Yenagoa, Bayelsa State, Nigeria.
This study evaluated the behavioural response and toxicity of paraquat dichloride to fingerlings of Clariasgariepinus. The fishes were acclimatized for 14 days and exposed to sublethal concentration of 0.00 ppm, 16.56 ppm, 22.08 ppm, 27.60 ppm, 33.12 ppm and 38.64 ppm. A 24 hours’ renewal bioassay was adopted in this study. Results showed that the fishes exhibited change in swimming, opercular movement, body pigmentation, surfacing and air gulping. Mortality rate increased significantly at p<0.05 as the concentration of the toxicant increased as well as the exposure period. LC50 values at 24, 48, 72 and 96 were 59.95, 47.59, 38.12 and 26.18ppm, respectively. Based on the results, Paraquat dichloride users need to discard the remains of empty cans properly to avoid contamination. Also there is need to exercise caution when using paraquat dichloride based herbicides in agricultural fields close to surface water resources.
Apr 2019 DOI 10.14302/issn.2324-7339.jcrhap-19-2711
M. Hussein AhmedCorresponding author
PhD, Assistant Professor, Shendi University, Faculty of Public Health, Head Department of Public Health
This is cross sectional descriptive community based study to measure the prevalence of Schistosomasis disease, multistage cluster sampling was taken (500person), and the data was collected by the flowing methods, Urine Examination, Stool examination, and Questionnaire, the data was analyzed by using (SPSS) the main result for study Schistosomosis Hematoupium was 15% and Schistosomosis Mansoni was Zero, the prevalence was high in Tibaha Alkhwad administrative unit with 6.0%, Almata with 5.2% and Wedhamid with 3.8%. The study found there was strong relation between Shistosomasis and both genders (male, female) where the prevalence was high among male 10.8%, the study also showed there was strong relationship between Schistosomasis and age groups, The prevalence increases among age group (15 to 25 years )with (5.8%), There was strong significant relation between swimming in stagnant water and getting infected with Schistosomasis, The prevalence increases among people go to swimming in stagnant water with 11.0% (PV =0.0000 significant),
Feb 2017 DOI 10.14302/issn.2476-1710.jdt-16-1346
D. Deiko RomanCorresponding author
Post-graduate student of the department of pharmacology of National University of Pharmacy
Theaim of study is to evaluate antidepressant-like activity of the new peptidergic neuroprotectoracetyl-(D-Lys)-Lys-Arg-Arg-amide, homologous of ACTH15-18 primary amino acids sequence, that demonstrates nootropic and neuroprotective properties. Using Porsolt swimming test (PST) efficacy of tetrapeptide neuroprotector KK-1 at a single dose of 0.02 mg/kg was investigated on 16 white random bred male rats (body mass equaled 180-220 grams). Imipramine (15 mg/kg i.p.) was used as a reference drug. Then depression was induced in these rats by reserpine (4 mg/kg, i.p.). The KK-1 (intranasally, i.n.) and imipramine were administered once a day during 3 days until the reserpine-induced depression was reproduced. The indices of rats behavior under the conditions of open-field test (OFT) and PST were evaluated. The influence of both drugs on specific reserpine-induced depressions symptoms (hypothermia and blepharoptosis) was also registered. The results were processed statistically. The tetrapeptide neuroprotector KK-1 reduced immobilization time of rats at PST (statistically significant differences compared with control group), exceeding efficacy of reference drug imipramine. Normalizing of locomotor and exploratory activity in the OFT, decreasing indices of rats helplessness behavior in PST by tetrapeptide neuroprotector KK-1 demonstrates its antagonism with depressive action of reserpine. The tetrapeptide KK-1 showed antidepressant-like action both in intact rats and in rats with the model of reserpine-induced depression. It reduced specific symptoms of depression – hypothermia and blepharoptosis, exceeding the activity of reference drug imipramine.