Research Topic · Peer-Reviewed

Proteomic Mass Spectrometry

Proteomic mass spectrometry is the application of mass spectrometric measurement to the large-scale identification and quantification of proteins in biological samples. Proteins or their enzymatically generated peptides are ionised and separated according to mass-to-charge ratio, and the resulting spectra are matche…

Curated from this journal's research 📚 11 peer-reviewed articles cited Cited 82× across the literature 🔖 ISSN 2326-0793 🗓 Reviewed July 2026

Overview

Proteomic mass spectrometry is the application of mass spectrometric measurement to the large-scale identification and quantification of proteins in biological samples. Proteins or their enzymatically generated peptides are ionised and separated according to mass-to-charge ratio, and the resulting spectra are matched against sequence databases to identify constituents and characterise post-translational modifications. Workflows are commonly described as bottom-up, in which proteins are digested before analysis, and shotgun approaches that profile complex mixtures, frequently coupled to liquid chromatography for upstream separation and to tandem mass spectrometry for sequence-level information. Quantification strategies range from label-free comparison of signal intensity to metabolic and chemical labelling methods such as stable isotope labelling, exemplified by SILAC, and ion-current-based measurement, enabling reproducible comparison of protein abundance between conditions. Affinity purification combined with mass spectrometry maps protein interactions and complexes. These capabilities support discovery of disease biomarkers, analysis of drug response and resistance mechanisms, characterisation of organism-wide proteomes, and the broader goals of the human proteome effort. Allied bioinformatics is essential for spectral interpretation, statistical validation, and biological inference. Applications extend across cancer research, diagnostics, personalised medicine, host-pathogen biology, and comparative proteome studies, making the technique a central analytical platform in Proteomics and Genomics Research.

Research published in this journal

11 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2013

Quantitative Proteomics Using 15N SILAC Mouse

I. Chen EmilyCorresponding author
Stony Brook University, Proteomics Center, School Of Medicine, NY
Proteomics and Genomics Research Cited by 4 doi:10.14302/issn.2326-0793.jpgr-13-252
2017

Shotgun Label-Free Proteomic Analyses of the Oyster Parasite Perkinsus Marinus

C. P. Figueiredo HenriqueCorresponding author
AQUACEN, National Reference Laboratory for Aquatic Animal Diseases, Ministry of Agriculture, Livestock and Food Supply, Federal University of Minas Gerais, Belo Horizonte, Brazil
Proteomics and Genomics Research Cited by 11 doi:10.14302/issn.2326-0793.JPGR-17-1571

How this research is being cited

The 11 articles above have been cited 82 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Proteomic Mass Spectrometry, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Proteomics and Genomics Research (ISSN 2326-0793).

Journal editorial board
Sutopa Dwivedi · United States Liuyang Wang · United States Juan Sainz · Spain

This page summarises published research for orientation; it is not medical or professional advice.