Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Rather than the infection alone, it is the maladaptive systemic reaction, with widespread endothelial activation, microvascular and coagulation derangement, and mismatched oxygen delivery, that injures tissues distant f…
Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Rather than the infection alone, it is the maladaptive systemic reaction, with widespread endothelial activation, microvascular and coagulation derangement, and mismatched oxygen delivery, that injures tissues distant from the original focus and can progress to septic shock with refractory hypotension and elevated lactate. Clinically it is recognized through organ-dysfunction scoring and supported by markers of inflammation and perfusion, and outcomes hinge on early source control, timely antimicrobial therapy and haemodynamic resuscitation. Survivors frequently face prolonged critical-illness sequelae requiring rehabilitation. Work in this area covers rehabilitation of sepsis patients in intensive care, rapid myocardial calcification as a sequela of severe sepsis, restriction of antimicrobial usage in a neonatal unit, the use of alveolar-arterial oxygen gradients and severity scoring in pneumonia and COVID-19 cohorts, and experimental systemic inflammatory response syndrome modelled by cecal slurry with LPS and Escherichia coli to study inflammatory cytokines. Related haematological derangements, including von Willebrand factor and ADAMTS13 abnormalities and disturbances in dengue haemorrhagic fever, situate sepsis within broader inflammatory and coagulation pathophysiology. The journal publishes peer-reviewed clinical and experimental research relevant to sepsis, critical illness and systemic inflammation.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 26 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Sepsis, linking to each citing work.