Research Topic · Peer-Reviewed

Tumor Suppressor Genes

Tumor suppressor genes are segments of DNA that encode proteins responsible for regulating cell division, repairing damaged DNA, and triggering programmed cell death when necessary. When these genes lose function through mutation or epigenetic silencing, cells may proliferate uncontrollably, contributing to cancer d…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 26× across the literature 🔖 ISSN 2372-6601 🗓 Reviewed July 2026

Overview

Tumor suppressor genes are segments of DNA that encode proteins responsible for regulating cell division, repairing damaged DNA, and triggering programmed cell death when necessary. When these genes lose function through mutation or epigenetic silencing, cells may proliferate uncontrollably, contributing to cancer development. Research published in Hematology and Oncology Research examines tumor suppressor genes across multiple contexts, including their role in pediatric acute lymphoblastic leukemia with chromosomal abnormalities, meningioma pathogenesis and progression, and colorectal carcinogenesis through serrated lesion pathways. Studies have investigated epigenetic mechanisms affecting gene expression, including nutritional influences on epigenetic modifications and microRNA regulation of genes like OCT4. Diagnostic applications include microRNA quantification for colon cancer screening and molecular approaches to thyroid cancer management. Research has also explored cellular mechanisms such as CDC6 cytoplasmic retention inducing senescence and suppressing tumor formation, as well as age-related changes in satellite cell regeneration involving multiple regulatory pathways. Understanding tumor suppressor gene function and dysfunction remains essential for elucidating cancer biology, identifying diagnostic markers, and developing targeted therapeutic strategies across hematologic malignancies and solid tumors.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2019

Genes in Tumor Formation

Riede IsoldeCorresponding author
Independent Cancer Research, Im Amann 7, Ueberlingen D-88662.
Exact topic Hematology and Oncology Research Cited by 2 doi:10.14302/issn.2372-6601.jhor-19-2986
2015

Epigenetics and Nutrition

Lundstrom KennethCorresponding author
PanTherapeuitcs, Rue des Remparts 4, CH1095 Lutry, Switzerland
Exact topic International Journal of Nutrition Cited by 2 doi:10.14302/issn.2379-7835.ijn-14-603
2017

Canine Periosteal Osteosarcoma

Noronha de Toledo GabrielaCorresponding author
Department of Clinic and Veterinary Surgery, School of Agricultural and Veterinary Sciences (FCAV), Universidade Estadual Paulista – UNESP, Campus Jaboticabal, SP, Brazil.
Exact topic Veterinary Healthcare Cited by 2 doi:10.14302/issn.2575-1212.jvhc-17-1574

How this research is being cited

The 12 articles above have been cited 26 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Tumor Suppressor Genes, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Hematology and Oncology Research (ISSN 2372-6601).

Journal editorial board
Jayadev Manikkam Umakanthan · United States Shuaiying Cui · United States Benedetto Sacchetti · Italy

This page summarises published research for orientation; it is not medical or professional advice.