Natural Antisense Transcripts

Natural Antisense Transcripts (NATs) refer to transcripts that have been identified from genomic regions that can produce a sequence of RNA which is complementary to the sense mRNA mRNA in a gene. These NATs are believed to serve a role in regulating gene expression, acting as a buffer against overexpression or silencing of gene function. NATs have been implicated in diseases such as cancer and autoimmune disorders and are being studied for potential therapeutic applications. By regulating gene expression, NATs may provide a new and unique approach for treating many diseases associated with malfunctions in gene expression. NATs could be used in the future to create targeted therapies for specific diseases and therefore improve patient outcomes.