Aims & Scope
Journal of Thrombosis and Treatments (JTT) publishes mechanistic research on the molecular and cellular pathophysiology of thrombotic disorders, focusing on disease mechanisms, biomarker discovery, and molecular targets rather than clinical management or therapeutic protocols.
Core Research Domains
Coagulation Cascade Mechanisms
Molecular investigations into blood coagulation pathways, protein interactions, and regulatory mechanisms.
- Coagulation factor structure-function relationships
- Tissue factor pathway regulation and signaling
- Thrombin generation mechanisms and feedback loops
- Fibrin polymerization and clot architecture
- Coagulation protein post-translational modifications
- Genetic variants affecting coagulation proteins
"Structural analysis of Factor Xa mutations and their impact on prothrombinase complex assembly"
Platelet Pathophysiology
Cellular and molecular mechanisms governing platelet activation, adhesion, aggregation, and signaling.
- Platelet receptor signaling pathways (GPIIb/IIIa, P2Y12, PAR)
- Platelet granule secretion mechanisms
- Platelet-endothelium interaction dynamics
- Platelet activation biomarkers and detection methods
- Megakaryocyte biology and thrombopoiesis
- Platelet microparticle formation and function
"Proteomic profiling of platelet alpha-granule contents in hypercoagulable states"
Fibrinolysis & Thrombus Resolution
Molecular mechanisms of clot breakdown, fibrinolytic system regulation, and thrombus remodeling.
- Plasminogen activation pathways (tPA, uPA)
- Fibrinolysis inhibitor mechanisms (PAI-1, TAFI)
- Fibrin degradation product formation and clearance
- Endothelial fibrinolytic capacity regulation
- Genetic determinants of fibrinolytic efficiency
- Thrombus stability and dissolution kinetics
"Molecular mechanisms of PAI-1 upregulation in metabolic syndrome and thrombotic risk"
Vascular Biology & Endothelial Dysfunction
Endothelial cell mechanisms in thrombosis, vessel wall interactions, and vascular homeostasis disruption.
- Endothelial activation pathways in thrombosis
- Von Willebrand factor biosynthesis and secretion
- Endothelial glycocalyx structure and function
- Vascular inflammation-thrombosis crosstalk
- Shear stress effects on endothelial phenotype
- Endothelial-derived microparticles in coagulation
"Mechanistic analysis of endothelial cell injury markers in venous thromboembolism pathogenesis"
Secondary Focus Areas
Thrombosis Biomarker Discovery
- Novel molecular biomarkers for thrombotic risk stratification
- Proteomic and metabolomic profiling in thrombotic states
- Circulating microRNA signatures in thrombosis
- Biomarker validation in preclinical models
- Point-of-care diagnostic technology development
Genetic & Molecular Epidemiology
- Thrombophilia genetic variants and penetrance
- Genome-wide association studies (GWAS) of thrombotic disorders
- Gene-environment interactions in thrombosis risk
- Epigenetic modifications in coagulation pathways
- Population-based molecular risk profiling
Inflammation-Thrombosis Interface
- Immunothrombosis mechanisms and pathways
- Neutrophil extracellular traps (NETs) in thrombosis
- Complement system activation in coagulation
- Cytokine-mediated procoagulant responses
- Inflammatory cell-platelet interactions
Computational & Systems Biology
- Mathematical modeling of coagulation dynamics
- Systems biology approaches to thrombosis networks
- Bioinformatics analysis of thrombosis datasets
- Machine learning for thrombotic risk prediction models
- Network analysis of hemostatic protein interactions
Emerging Research Frontiers
Explicitly Out of Scope
- Clinical Treatment Protocols & Therapeutic Guidelines: Studies focused on anticoagulant dosing regimens, treatment algorithms, clinical management pathways, or comparative effectiveness of therapies without mechanistic investigation.
- Clinical Outcome Trials & Patient Management: Randomized controlled trials, observational outcome studies, quality improvement initiatives, or healthcare delivery research without molecular/cellular mechanistic components.
- Surgical Techniques & Procedural Interventions: Descriptions of surgical approaches, catheter-based interventions, or procedural modifications unless accompanied by substantial mechanistic analysis of thrombotic processes.
- Clinical Case Reports & Case Series: Individual patient cases or small case series without novel mechanistic insights, biomarker discovery, or pathophysiological investigation.
- Drug Pharmacokinetics Without Mechanism: Pure pharmacokinetic studies, drug absorption/distribution/metabolism/excretion (ADME) profiles, or therapeutic drug monitoring without mechanistic investigation of drug-target interactions or pathway effects.
Rationale: As a pathophysiology-focused journal, JTT prioritizes understanding disease mechanisms over clinical application. Research that primarily addresses "how to treat" rather than "how disease works" is better suited for clinical or therapeutic journals.
Article Types & Editorial Priorities
Priority 1: Fast-Track
Target Decision: 21 Days- Original Research Articles
- Systematic Reviews & Meta-Analyses
- Methods & Protocols
- Registered Reports
Priority 2: Standard Review
Target Decision: 35 Days- Short Communications
- Data Notes & Datasets
- Perspectives & Commentaries
- Technical Notes
Priority 3: Selective
Pre-Submission Inquiry Required- Hypothesis Articles
- Opinion Pieces
- Historical Perspectives
- Educational Reviews
All article types must present mechanistic insights into thrombosis pathophysiology. Purely descriptive or clinical observational studies without molecular/cellular investigation are not considered.
Editorial Standards & Requirements
Reporting Guidelines
All submissions must adhere to appropriate reporting standards:
- ARRIVE 2.0: Animal research
- MIQE: qPCR experiments
- PRISMA: Systematic reviews
- STROBE: Observational studies (if mechanistic)
- STARD: Diagnostic biomarker studies
Data Transparency
JTT requires comprehensive data sharing:
- Raw data deposition in public repositories
- Complete protocols and reagent details
- Statistical analysis code availability
- Biological materials sharing agreements
- Negative results and null findings reporting
Ethics & Reproducibility
Mandatory compliance requirements:
- Institutional ethics approval for all human/animal studies
- Informed consent documentation
- Conflict of interest disclosure
- Sample size justification and power analysis
- Blinding and randomization procedures
Preprint Policy
JTT supports open science practices:
- Preprint posting encouraged (bioRxiv, medRxiv)
- No impact on manuscript consideration
- Preprint DOI must be disclosed at submission
- Preprint versions updated upon acceptance
- Preprint-to-publication linking maintained
