Cartilage Homeostasis

Cartilage homeostasis refers to the maintenance of healthy cartilage within the body. Cartilage is a type of connective tissue made up of cells and extracellular matrix that primarily provides support, cushioning, and lubrication to enable movement. Cartilage homeostasis is essential for optimal musculoskeletal health and enables normal functioning of joints. Impaired cartilage homeostasis can lead to joint degeneration and diseases such as osteoarthritis, rheumatoid arthritis, and gout. Factors such as physical trauma, age, obesity, and genetic predisposition can contribute to disruption of cartilage homeostasis. Several therapies have been developed to help restore cartilage homeostasis, including cell- and stem-cell-based treatments, gene therapy, and the use of biologics.