As shown in (Figure 1, Figure 2) the incidence of post-operative epistaxis and atrophic rhinitis was correlated to two significant factors which are the age of patient and the type of performed technique. It was found that the PIT increased significantly the risk of post-operative bleeding and atrophic rhinitis up to (20%) and (35%) consecutively among elderly patients as compared to SMD (P < 0.05). On the other hand, as illustrated in (Figure 3) the incidence of post-operative recurrence of HIC was correlated to the patient related environmental and habitual factors. It was found that SMD is associated with higher percentage of recurrence (30%) as compared to PIT among heavy smoking patients as well as the patients with history of usual exposure to allergic rhinitis inducing allergens (P < 0.05). In accordance the (Table 1) elucidate the effect of patients' local health status on outcomes of the inferior concha surgery, it was found that the patients with allergic rhinitis and vasomotor rhinitis who operated by PIT showed a significant long-standing improvement may reach up to 93% as compared to those who interfered by SMD (P < 0.05). As demonstrated in (Table 2) the effect of patients' general health status in relation to the type of performed procedure. It was confirmed that the patients with uncontrolled systemic hypertension had a significant raising in the risk of post-operative epistaxis after PIT as compared to SMD and those patients with uncontrolled diabetes mellitus shown higher risk of recurrence of nasal obstruction after SMD as compared to PIT (P < 0.05). On the other hand, (Figure 4) was elucidated the comparison between two techniques in relation to operative time consumption, it was found that the duration of PIT was significantly longer as compared to SMD (P < 0.05). Therefore from economic point of view, as illustrated at (Table 3) PIT can be classified significantly with higher expense as compared to SMD (P < 0.05). From other side, as can be seen from (Table 4) the amount of direct or indirect reduction of inferior conchae size had a significant effect on outcomes of the performed procedure. As it is presented at the same table these results was correlated with number of cauterization points in SMD, and the resected size of inferior concha in PIT. On the other hand there was significant improvement for outcomes of SMD and PIT if they are performed concomitantly with septoplasty procedure (P < 0.05).

The inferior concha surgery is commonly performed therefore it always needs to improve its outcomes. Although during last two centuries there are many published clinical studies which tried to present new techniques that may had been proved with better outcomes of this surgery but still as concluded at other many clinical trials and observations that it may become very difficult to decide which technique is most suitable modality for the selected candidate. It was found that there are many factors, which may be determine difficulties regarding the selection of most proper manner of inferior conchae surgery 1516171819202122232425262728293031323334353637383940. However most of the recent studies tried to resolve these difficult situations but from the surgical side it was noted that in spite of following of these studies recommendations, unpredicted post-operative outcomes still appearing. Thus this type of surgery can be classified as one of the dilemmas at rhinology.

Regarding the selection of the patient who should be considered as most suitable candidate for inferior turbinate surgery, generally speaking the inferior conchae surgery can be elective and non-elective i.e. when this pattern of surgery is decided to be performed for the management of persistent mechanical nasal obstruction at this case it will be classified as elective surgery 1234567891011121314151617181920. On the other hand, the inferior turbinatectomy can be conducted non-electively as a part of wide resection of sino-nasal neoplastic lesions 262728293031323334353637383940. Our discussion is mainly highlight the elective category of this surgery. Basically there are five major criteria according to which the patient might be indicated for inferior concha surgery:

The patient has chronic nasal obstruction related presentations this can be as partial or complete inability to breathe through the nose, frequent or persistent opened mouth for mouth breathing, olfaction function impairment, sleep related breathing disorders, and recurrent sore throat, pharyngitis, as well as oral ulcers due to persistent mouth breathing.

The patient received sufficient medical therapy in form of local steroids, local nasal douching, systemic steroids, and systemic anti-histamines for enough time which is 3-6 months but the patient did not show any significant clinical improvement.

The patient proved locally that has significant (HIC) which occupies more than one-third of nasal cavity.

The HIC grossly appears as enlarged turbinate with thick, pale, grayish-white, and non-shiny covering mucosa.

The significant nasal obstruction due to HIC, must be elucidated objectively by positive rhino-metric evaluation, and\ or positive Cottle's sign, and\ or positive impairment of olfactory function.

Hence, the patient was selected as indicated candidate for inferior turbinate surgery; the next step will be the selection of most proper technique for that particular patient. there are two modalities of inferior turbinate surgical techniques namely; a) PIT which can be done by lateral resection of maximum up to one-third of HIC either by using curved scissors, or shaver, or radio-frequency ablation, or co-ablation 1234567891011121314151617181920272829303132333435363738394041. b) SMD, this technique is considered as old fashion for inferior turbinate surgery. It is performed by creation of electrical cauterization at multiple points (2-5 points) through sub-mucosal layer of HIC. This technique acts mainly by cauterization of sub-mucosal venous sinusoids among HIC with active sensitization inflammatory process due to allergic rhinitis, vasomotor rhinitis, or rhinitis medica-mentosa. Thus the sub-mucosal fibrosis will be induced subsequently as a reaction to venous sinusoids cauterization and this will result in the shrinkage of inferior turbinate bulk. However, the submucosal diathermy technique was proved very effective and simple technique but still it is of no benefits among those patients with HIC due to increase in bulk of concha bone rather than soft tissue 1234567891011121314151617181920.

We noted throughout our long-term experience, which extend for more than fifteen years that the following of the recommendations that usually came out from several old as well as recent studies regarding inferior conchae surgeries did not sufficiently give the suggested results as those studies concluded. For this reason, we tried through this proposed serial study to predict the factors that may had been thought to be significant factors affecting outcomes of this surgery. Moreover, these studied factors can be discussed as: a) Patient's age, the elderly patients showed higher incidence of post-operative epistaxis and the atrophic rhinitis as compared to the younger people. In the same manner, the incidence of post-operative epistaxis as well as atrophic rhinitis significantly increased by interfering with PIT as compared to SMD. This can be explained by basic-physiological fact, that vascular related aging process among elderly patients constitutes the major predisposing factor for the impairment of local homeostasis control after the surgery and the delay of proper healing process at the site of surgery. Also, the significant decrease in the number of venous sinusoids and mucosal glandular acini at sub-mucosal layer of the concha among elderly patient. 1227282930313233343536373839404142434445. Thus PIT might not be considered as most suitable selection for inferior conchae surgery among old ages. b) Patient related habitual and environmental factors, there was significant increased the incidence of post-operative recurrence of HIC by smoking and chronic exposure to certain allergens as pollens, animal epithelial, house dust mites, and chemical irritants as compared to the non-smokers and those patients who are not frequently exposed to environmental irritants. c) Patient's local health status, as can be elucidated from this serial study that the local nasal pathological status of the patient might affect significantly the decision regarding the selection of most proper technique of inferior concha surgery. i.e. those patients who presented as cases of allergic rhinitis and vasomotor rhinitis got significant long standing improvement regarding the patency of nose after PIT as compared to SMD. This might be due to the sufficient amount of tissue which resected by PIT. On the other hand, the basic idea behind the conduction of SMD is to reduce the number of venous sinusoids and to stimulate the diffuse fibrosis at the level of sub-mucosal layer of inferior turbinate. These effects had been proved to be not sufficient to fulfill the adequate maintenance of optimum size of inferior turbinate because still there is risk of re-proliferation of the venous sinusoids and recurrence of hypertrophy of inferior turbinate. Thus, the most suitable techniques for inferior turbinate surgery among patients with allergic rhinitis or vasomotor rhinitis is PIT 12345678910111213141516171819202122232425262728293031. d) Patient's systemic health status, this presenting study demonstrated that the risk of epistaxis is increased after PIT among hypertensive patients as well as diabetic patients; this can be explained by extensive local tissue injury due to PIT as compared to other less invasive techniques. in accordance, the SMD results in increased risk of recurrence of nasal obstruction among patients with diabetes mellitus as compared to PIT. This can be reasoned to that, the patients with diabetes mellitus are more prone for local atrophic changes and diffuse fibrosis as compared to non-diabetic patients. This is due to high incidence of local diabetic angiopathic changes. In addition, the higher incidence of vasomotor rhinitis among diabetic patients as compared to non-diabetic patients, this will increase the risk of recurrence of mechanical nasal obstruction due to inferior turbinate hypertrophy. Accordingly, we can recommend that the PIT is not the suitable technique for hypertensive and diabetic patients; also, SMD is not the curable procedure for patient with diabetes mellitus 1234567891011121314151617181920212223242526272829.

In same manner, there is another important factor, which may play an important role in the rooting of these difficulties of this surgery namely the socio-economic factor. As it was illustrated from this study and via the rough evaluation of different economic aspects for each performed technique, including the expense of used drugs, nasal packing, patient word stay, and post-operative patient follow-up it was found that PIT had higher prices as compared to SMD. The PIT is described as more invasive technique which consume longer operative duration thus the amount of utilized anesthesia drugs will be more. in addition to certain specific drugs which might be needed to be administrated as tranxiemic acid for purpose of epistaxis control which will be more among PIT 2021222324252627282930313233343536373839404142434445. In accordance, patients after PIT need to be cared more as compared to other technique this will result in the prolongation of patient's post-operative stay at word. In addition, the patients after PIT needs repetitive follow-up sessions. This is because of high tendency for recurrent local dryness and crusts formation during first 4-6 weeks post-operatively, which may predispose to infective rhinitis that leads to healing by scaring and synaechia formation. However the PIT is representing a very effective procedure for the surgical management of persistent mechanical nasal obstruction due to HIT but still it is considered as expensive procedures as compared to SMD 1011121314151617181920212223242545.

From the other view, we tried at our serial to postulate whether the concomitant septoplasty has any role regarding improvement of outcomes of inferior concha surgery. Indeed, we found that the septoplasty even for mild deviated nasal septum as bothersome procedure with inferior concha surgery might improve significantly the outcomes of this surgery. This can be reasoned by reducing the points of cauterization among SMD cases and limitation of the tissue resection among PIT cases. Thus, the risk of post-operative functional nasal obstruction due to atrophic rhinitis is significantly decreased 3536373839404142434445.

Finally, we can conclude to that really the inferior concha surgery is considered as one of difficult dilemmas at rhinology and because it is widely conducted surgery thus always, it needs frequent research to resolve all possible associated problems and issues 45. The cornerstone of this dilemma is how to avoid the adverse outcomes of inferior concha surgery45. As it can be noted from the results of this serial study, the results were confirming and approving the conclusion of our previously conducted study on 201545 We tried through this serial study to extend our previous study just by increasing the number of cases and expand the period of follow up for the operated patients45.

Although this study was not so well-controlled, but it is long-standing, and of adequate number of cases, but as previous study. Therefore, as other suggested recommendation, the further clinical studies are advised to be committed to confirm these concepts which obtained from this presenting study and in the same time the new aims may be suggested to be illustrated to find proper answer for these big titled questions.