Aims & Scope

Journal of Fertility Biomarkers publishes mechanistic research on biological markers that regulate reproductive function, gamete quality, embryo development, and fertility potential across species.

Reproductive Biomarkers Gamete Biology Embryo Development Fertility Mechanisms Reproductive Physiology

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Core Research Domains

Gamete Biology & Quality Markers

Oocyte maturation biomarkers and developmental competence
Sperm quality indicators: motility, morphology, DNA integrity
Molecular markers of gamete aging and oxidative stress
Epigenetic modifications in germ cells
Metabolomic profiling of gametes
Proteomic signatures of fertilization potential

Typical fit: Identification of novel protein markers in follicular fluid that predict oocyte developmental competence in mammalian models.

Embryo Development & Implantation

Preimplantation embryo metabolism and viability markers
Blastocyst quality assessment biomarkers
Endometrial receptivity molecular signatures
Embryo-maternal communication molecules
Trophoblast differentiation markers
Early developmental gene expression patterns

Typical fit: Transcriptomic analysis of endometrial tissue identifying biomarkers of receptivity during the implantation window.

Reproductive Hormones & Signaling

Gonadotropin regulation and receptor signaling
Steroid hormone biosynthesis and metabolism
Anti-Müllerian hormone (AMH) as ovarian reserve marker
Inhibin, activin, and follistatin in fertility regulation
Leptin, adiponectin, and metabolic hormone effects
Novel peptide hormones in reproductive function

Typical fit: Mechanistic study of AMH signaling pathways in follicular development using in vitro ovarian culture systems.

Molecular & Genetic Biomarkers

Genetic polymorphisms affecting fertility phenotypes
MicroRNA regulation of reproductive processes
DNA methylation patterns in reproductive tissues
Chromosomal integrity markers in gametes and embryos
Gene expression profiling in reproductive organs
Mitochondrial DNA markers and fertility

Typical fit: Genome-wide association study identifying SNPs associated with ovarian reserve markers in diverse populations.

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Secondary Focus Areas

Reproductive Physiology

Ovarian folliculogenesis, corpus luteum function, spermatogenesis dynamics, hormonal feedback mechanisms, and reproductive cycle regulation.

Reproductive Endocrinology

Hypothalamic-pituitary-gonadal axis function, hormone receptor biology, endocrine disruption effects on fertility, and metabolic influences on reproduction.

Comparative Reproductive Biology

Cross-species fertility biomarker studies, evolutionary perspectives on reproductive mechanisms, and animal model development for human fertility research.

Reproductive Immunology

Immune cell populations in reproductive tissues, cytokine profiles affecting fertility, maternal-fetal immune tolerance mechanisms, and inflammatory biomarkers.

Oxidative Stress & Fertility

Reactive oxygen species in gametes, antioxidant defense systems, oxidative damage biomarkers, and redox regulation of reproductive processes.

Methodological Innovations

Novel assay development for fertility biomarkers, imaging techniques for reproductive tissues, high-throughput screening methods, and validation of biomarker panels.

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Emerging Research Frontiers

Selective Consideration with Additional Review

Artificial Intelligence Applications: Machine learning models for biomarker pattern recognition and fertility prediction based on biological data.

Single-Cell Omics: Single-cell RNA sequencing, proteomics, and metabolomics of reproductive cells revealing cellular heterogeneity.

Extracellular Vesicles: Exosome and microvesicle cargo as biomarkers of gamete quality and embryo-maternal communication.

Microbiome Interactions: Reproductive tract microbiome composition and metabolites affecting fertility through biological mechanisms.

Circadian Biology: Chronobiological regulation of reproductive hormones and fertility biomarkers across circadian and seasonal cycles.

Environmental Biomarkers: Molecular markers of environmental toxicant exposure affecting reproductive function and gamete quality.

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Article Types & Editorial Priorities

PRIORITY 1: Fast-Track Review

Preferred Submissions

Original Research Articles Systematic Reviews & Meta-Analyses Methods & Protocols Validation Studies

PRIORITY 2: Standard Review

Regular Consideration

Short Communications Data Notes Technical Notes Perspectives & Commentaries Mini-Reviews

PRIORITY 3: Rarely Considered

Exceptional Cases Only

Case Reports (only with novel biomarker discovery) Opinion Pieces (by invitation only) Editorials (by invitation only)

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Editorial Standards & Requirements

Reporting Guidelines

ARRIVE 2.0 for animal studies
STROBE for observational studies
PRISMA for systematic reviews
MIQE for qPCR experiments
MIAME for microarray data

Data Transparency

Raw data deposition in public repositories
Omics data: GEO, ArrayExpress, or PRIDE
Protocols shared via protocols.io or similar
Code availability for computational analyses
Material availability statements required

Ethics & Compliance

IRB/Ethics committee approval for human studies
IACUC approval for animal research
Informed consent documentation
Declaration of competing interests
Funding source disclosure

Preprint Policy

Preprints welcomed (bioRxiv, medRxiv)
Disclose preprint DOI at submission
No impact on novelty assessment
Preprint citation in published version
Simultaneous submission prohibited

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Decision Metrics & Publication Timeline

21 Days to First Decision (Median)

56% Acceptance Rate (2023)

45 Days to Publication (Post-Acceptance)

Open Article Processing Charges (APC)

Ready to Submit Your Research?

If your work focuses on biological mechanisms of fertility biomarkers, we want to hear from you. Our editorial team provides constructive feedback to advance reproductive biology research.

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Journal of Fertility Biomarkers

Journal of Fertility Biomarkers – Aim And Scope