Journal of Hematology and Oncology Research

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Hematology and Oncology Research-Cancer biomarker research. -Umit Tapan

United States

Boston University Medical Center

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Umit Tapan

Address:

820 Harrison Avenue
FGH Building 1st Floor
Boston, MA, 02118
United States

Research Interests:

Cancer biomarker research.

Biography:

  • My interest in clinical research started during my residency. 
  • While at a tertiary referral cancer center in Turkey I had the opportunity to contribute to several clinical research projects. 
  • One of these studies evaluated the frequency and determinants of metabolic syndrome in breast cancer patients. 
  • Our exciting results shed light into possible contribution of aromatase inhibitors to development of metabolic syndrome. 
  • Through another study on management of brain metastases from breast cancer, we were able to elucidate clinical prognostic factors for this dismal condition. 
  • I was fortunate to continue my journey in the field of clinical research in the United States during internal medicine residency and currently with a Hematology/Oncology fellowship at Boston University. 
  • During first year of my residency I designed and performed a retrospective study which revealed high B-natriuretic peptide levels in amyloidosis patients treated with lenalidomide. 
  • It was the first study reporting such association; the results were presented at ASH 2012 and was published in Blood Journal. 
  • I also had the opportunity to design, conduct and analyze a retrospective study looking into the association between heparin-platelet factor 4 antibody and mortality. 
  • The results were presented at ASH 2013 and is under review for publication in Platelet Journal. 
  • Currently, while in my fellowship, I am focusing on the predictive role of a biomarker for EGFR targeted therapy in metastatic colorectal cancer patients, which I think will have a major impact on how we treat colorectal cancer patients. 
  • The study is currently at the last stage with completion of pathological assessment of biomarkers and pending for analysis of the association between clinical responses and level of biomarker expression. 
  • The hands-on experience I had in the translational lab was invaluable and encouraged me to continue with further translational projects.
  • I am also working on a retrospective study in different cancer types, to look for the association between topo-I-pS10 levels and clinical response to topo-I inhibitors. 

Positions and Honors.   
Positions:        

  • 06/2005 - 05/2009       Internal Medicine Residency, Hacettepe Univ. Hospital, Ankara, Turkey
  • 06/2009 - 06/2012       Internal Medicine Residency, Steward Carney Hospital, Boston, MA
  • 07/2012 - Present        Hematology/Oncology Fellowship, Boston University Medical Center, Boston, MA

Honors:

  • 12/1998 - Ranked 1st in the Eastern Region in the National Biology Exam (Turkey)
  • 06/2000- Ranked in top 1% in the National University Entrance Exam (Turkey)
  • 09/2006- Ranked in top 1% in the National Medical Residency Exam (Turkey)
  • 11/2009- Ranked in top 10% in the National Internal Medicine In-service Exam (USA)
  • 06/2014- Selected as chief fellow for Hematology/Oncology Fellowship at Boston Medical Center matol.
  • 2008 May- 80 (5):381-5.