About the Journal of Immunology and Geriatrics
Advancing mechanistic understanding of immune aging, age-related immunopathology, and molecular pathways that define immune dysfunction across the lifespan.
Decoding Immune System Pathophysiology in Aging Populations
The Journal of Immunology and Geriatrics (JIG) is a peer-reviewed, open access platform dedicated to unraveling the molecular mechanisms underlying immune system changes during aging. Our mission centers on understanding how immunity evolves, deteriorates, or adapts at the cellular and molecular level — from inflammaging pathways to immunosenescence biomarkers — rather than clinical treatment protocols.
JIG publishes mechanistic research that illuminates the pathophysiology of age-associated immune dysfunction, autoimmunity in elderly populations, and the molecular basis of immune-mediated disease progression. We bridge immunology and geriatric science through rigorous investigation of cellular signaling, genetic determinants, epigenetic modifications, and disease model systems that reveal fundamental principles of immune aging.
JIG's scope is deliberately focused on mechanistic understanding rather than clinical practice. We prioritize research that explains molecular pathways, identifies biomarkers, characterizes disease models, and reveals cellular mechanisms underlying immune dysfunction in aging. Our editorial framework excludes clinical diagnosis, treatment protocols, patient management strategies, and therapy guidelines — instead concentrating on the fundamental biology that precedes clinical translation.
Within Our Scope
- Molecular mechanisms of immunosenescence
- Inflammaging pathway analysis
- Biomarker discovery for immune aging
- Cellular models of age-related immune dysfunction
- Genetic determinants of immune response decline
- Epigenetic regulation of immune cell aging
- Pathogenesis of age-associated autoimmunity
- Molecular targets in immune system decline
Outside Our Scope
- Clinical diagnosis protocols
- Treatment guidelines for elderly patients
- Patient management strategies
- Clinical outcomes research
- Therapy efficacy studies
- Pharmaceutical intervention trials
- Care delivery models
- Healthcare service research
JIG advances pathophysiological knowledge across interconnected domains of immune system biology and aging science. Our editorial priorities reflect the molecular complexity of immune aging while maintaining disciplinary focus on mechanism over application.
Molecular characterization of thymic involution, T cell exhaustion, B cell dysfunction, natural killer cell decline, and cellular pathways driving age-related immune deterioration.
Chronic low-grade inflammation mechanisms including SASP signaling, cytokine networks, NF-κB activation, mitochondrial dysfunction, and cellular senescence markers in immune cells.
Molecular basis of autoimmune disease emergence in elderly populations, breakdown of self-tolerance mechanisms, autoreactive cell expansion, and genetic susceptibility factors.
Pathophysiology of macrophage polarization shifts, dendritic cell dysfunction, neutrophil behavior changes, complement system dysregulation, and pattern recognition receptor signaling in aging.
Cellular and molecular mechanisms underlying clonal expansion defects, memory cell dysfunction, antibody response impairment, and repertoire contraction in aging immune systems.
Gene expression profiling, DNA methylation patterns, histone modifications, microRNA regulation, and genetic polymorphisms influencing immune aging trajectories.
Identification and validation of molecular, cellular, and genetic biomarkers predicting immune aging status, disease susceptibility, and mechanistic pathway activation.
Development and characterization of animal models, cellular systems, organoid platforms, and computational models recapitulating immune aging pathophysiology.
Metabolic reprogramming of immune cells, mitochondrial dynamics, oxidative stress pathways, NAD+ metabolism, and nutrient sensing mechanisms affecting immune function.
JIG maintains a streamlined submission workflow designed to support researchers investigating complex immunological mechanisms. Our editorial team provides rapid initial assessment, constructive peer review, and transparent communication throughout the publication journey.
Manuscript Preparation
Review our author guidelines to ensure your mechanistic research aligns with JIG's pathophysiological focus. Manuscripts should emphasize molecular mechanisms, cellular pathways, and disease model insights.
Electronic Submission
Submit manuscripts through our online portal or via email to [email protected]. Include cover letters highlighting mechanistic novelty and pathophysiological significance.
Rigorous Peer Review
Expert reviewers evaluate mechanistic rigor, experimental design, data interpretation, and relevance to immune aging pathophysiology. Our peer review process maintains high standards while providing constructive feedback.
Rapid Publication
Accepted manuscripts undergo efficient production processing, ensuring swift dissemination of mechanistic discoveries to the global research community through our open access platform.
Authors choosing JIG benefit from a publication model specifically designed to amplify mechanistic research in immune aging while maintaining rigorous scientific standards.
- Mechanistic Focus: Editorial expertise in molecular pathophysiology ensures your research reaches specialists who value mechanistic depth over clinical application.
- Open Access Visibility: Immediate global availability maximizes impact among immunologists, molecular biologists, and aging researchers worldwide.
- Rigorous Quality Control: Expert peer review by scientists specializing in immune mechanisms and aging biology guarantees scientific integrity.
- Efficient Processing: Streamlined editorial workflows respect researchers' time while maintaining thorough evaluation standards.
- Diverse Article Formats: We accept original research, mechanistic reviews, methodology papers, and perspective articles exploring pathophysiological concepts.
JIG's editorial board comprises internationally recognized experts in immunology, molecular biology, genetics, and aging science. Our editors bring deep expertise in mechanistic research methodologies and maintain commitment to publishing scientifically rigorous investigations of immune system pathophysiology.
Advance Immunology & Geriatrics Research
Join the growing community of scientists investigating molecular mechanisms of immune aging. Submit your pathophysiological research to JIG and contribute to fundamental understanding of how immunity changes across the lifespan.
